Genomic Approaches to Investigate the Pathogenicity of Cryptococcus neoformans

被引：0
|
作者：
Mitchell, Thomas G. [1 ]
机构：
[1] Duke Univ, Med Ctr, Dept Mol Genet & Microbiol, Box 3803,Room 214,Jones Bldg,Res Dr, Durham, NC 27710 USA
来源：
CURRENT FUNGAL INFECTION REPORTS | 2008年 / 2卷 / 03期
基金：
美国国家卫生研究院;
关键词：
D O I：
10.1007/s12281-008-0025-z
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
Cryptococcus neoformans, a model pathogenic fungus, exemplifies the application of several genome-wide approaches to investigate fungal pathogenicity. This review focuses on the application of genome-wide approaches to large populations of clinical and environmental isolates rather than to a small number of well-defined laboratory strains. Specific examples include the construction and utilization of genetic linkage maps, analyses of quantitative trait genes and loci, and the use of genome-wide genetic markers in population studies.
引用
收藏
页码：172 / 179
页数：8
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