5-NITROFURAN DERIVATIVES OF FATTY-ACID HYDRAZIDES INDUCE DIFFERENTIATION IN HUMAN MYELOID LEUKEMIC-CELL LINES

被引：23

作者：

SUR, P ^{[1
]}

CHATTERJEE, S ^{[1
]}

ROY, P ^{[1
]}

SUR, B ^{[1
]}

机构：

[1] JADAVPUR UNIV,DEPT CHEM,CALCUTTA 700032,W BENGAL,INDIA

来源：

CANCER LETTERS | 1995年 / 94卷 / 01期

关键词：

DIFFERENTIATION; MYELOID LEUKEMIC CELLS; 5-NITROFURAN DERIVATIVES; FATTY ACID HYDRAZIDES;

D O I：

10.1016/0304-3835(95)03819-I

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Compounds formed by 5-nitrofuran with hydrazides of formic, acetic and propionic acids, hereafter respectively known as SBF, SBA and SBP have been used to evaluate the differentiation-inducing properties on two established myeloid leukaemic cell lines ML-2 and EOL-1. SBP is found to be the most effective as an antineoplastic agent amongst the three. Induction of differentiation observed are in the order SBP > SBA > SBF as assessed by morphology, NBT-reducing activity and surface marker antigens of the treated cells. Induction of differentiation of ML-2 and EOL-1 cells by the most effective compound, SBP (3 mu M), is accompanied by perturbation of the cell cycle, with most of the cells accumulating in the G(0)-G(1), phase. Inhibition of DNA synthesis occurs while protein and RNA synthesis remain practically unchanged.

引用

页码：27 / 32

页数：6

共 50 条

[1] LYMPHOCYTE DERIVED DIFFERENTIATION INDUCING FACTORS FOR HUMAN MYELOID LEUKEMIC-CELL LINES
OLSSON, IL
BREITMAN, TR
SARNGADHARAN, MG
GALLO, RC
CLINICAL RESEARCH, 1981, 29 (02): : A521 - A521
[2] NONHISTONE PROTEIN ANTIGEN PROFILES OF 5 LEUKEMIC-CELL LINES REFLECT THE EXTENT OF MYELOID DIFFERENTIATION
GOLDBERGER, A
BREWER, G
HNILICA, LS
BRIGGS, RC
BLOOD, 1984, 63 (03) : 701 - 710
[3] INDUCTION OF CYTOSKELETON-ASSOCIATED PROTEINS DURING DIFFERENTIATION OF HUMAN MYELOID LEUKEMIC-CELL LINES
BERNAL, SD
CHEN, LB
CANCER RESEARCH, 1982, 42 (12) : 5106 - 5116
[4] INHIBITORS OF TYROSINE PHOSPHORYLATION INDUCE APOPTOSIS IN HUMAN LEUKEMIC-CELL LINES
BERGAMASCHI, G
ROSTI, V
DANOVA, M
PONCHIO, L
LUCOTTI, C
CAZZOLA, M
LEUKEMIA, 1993, 7 (12) : 2012 - 2018
[5] DISSOCIATION OF C-FOS INDUCTION FROM MACROPHAGE DIFFERENTIATION IN HUMAN MYELOID LEUKEMIC-CELL LINES
CALABRETTA, B
MOLECULAR AND CELLULAR BIOLOGY, 1987, 7 (02) : 769 - 774
[6] ANTIMICROTUBULE AGENTS INDUCE POLYPLOIDIZATION OF HUMAN LEUKEMIC-CELL LINES WITH MEGAKARYOCYTIC FEATURES
VANDERLOO, B
HONG, Y
HANCOCK, V
MARTIN, JF
ERUSALIMSKY, JD
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, 1993, 23 (10) : 621 - 629
[7] EFFECTS OF BONE-MARROW FIBROBLASTS ON THE PROLIFERATION AND DIFFERENTIATION OF MYELOID LEUKEMIC-CELL LINES
STOLZE, B
EMMENDORFFER, A
CORBACIOGLU, S
KONIG, A
WELTE, K
EBELL, W
EXPERIMENTAL HEMATOLOGY, 1995, 23 (13) : 1378 - 1387
[8] MOLECULAR AND CELLULAR EFFECTS OF HEXADECYLPHOSPHOCHOLINE (MILTEFOSINE) IN HUMAN MYELOID LEUKEMIC-CELL LINES
BECKERS, T
VOEGELI, R
HILGARD, P
EUROPEAN JOURNAL OF CANCER, 1994, 30A (14) : 2143 - 2150
[9] DIFFERENTIATION-ASSOCIATED CHANGES OF CATION-TRANSPORT ACTIVITIES IN MYELOID LEUKEMIC-CELL LINES
REPHAELI, A
AVIRAM, A
ENGLENDER, T
SHAKLAI, M
FEBS LETTERS, 1988, 236 (02) : 401 - 405
[10] MEMBRANE DIFFERENTIATION IN HUMAN MYELOID CELLS - EXPRESSION OF UNIQUE PROFILES OF CELL-SURFACE GLYCOPROTEINS IN MYELOID LEUKEMIC-CELL LINES BLOCKED AT DIFFERENT STAGES OF DIFFERENTIATION AND MATURATION
FUKUDA, M
KOEFFLER, HP
MINOWADA, J
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1981, 78 (10): : 6299 - 6303

← 1 2 3 4 5 →