SUCCESSFUL TREATMENT OF POLYARTERITIS-NODOSA WITH LOW-DOSE METHOTREXATE

被引：5
|
作者：
BRODY, M
BOHM, I
BIWER, E
BAUER, R
机构：
来源：
HAUTARZT | 1994年 / 45卷 / 07期
关键词：
POLYARTERITIS-NODOSA; INTERLEUKIN-1; INTERLEUKIN; 8; TUMOR NECROSIS FACTOR-ALPHA; METHOTREXATE;
D O I：
10.1007/s001050050108
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
We report on a 45-year-old male patient who presented a classic polyarteritis nodosa (PAN). The clinical course extended over 7 years. In spite of 2 years immunosuppressive therapy with azathioprine and methylprednisolone the course was progressive. Low-dose methotrexate therapy was the only treatment that controlled the disease, leading to rapid clinical and histopathological remission. In low concentrations methotrexate acts as an IL-1 inhibitor, and it obviously suppresses the pathogenetic mechanism of PAN.
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页码：476 / 479
页数：4
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