SYNTHESES OF FUNCTIONALIZED N-(2-PYRIDYL)-ALPHA-AMINO ACIDS AND ESTERS BY RING-OPENING OF IMIDAZO[1,2-A]PYRIDINE

被引：0
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作者：
DOISE, M
BLONDEAU, D
SLIWA, H
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来源：
HETEROCYCLES | 1992年 / 34卷 / 11期
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中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
This report is devoted to the ring opening of the imidazole nucleus of functionalized imidazo[1,2-a]pyridines, by methanol in strong acid medium (HClO4) leading to esters of N-(2-pyridyl)-alpha-amino acids in which the heterocyclic moiety bears a functional group. Direct obtention of this kind of compounds could be achieved by condensation of glyoxal derivatives with ethers of 2-amino-3-hydroxypyridine or with 2-amino-3(or 5)-nitropyridine in methanolic perchloric acid.
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页码：2079 / 2093
页数：15
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