A COMPARATIVE-STUDY OF DRUG-METABOLIZING-ENZYMES IN ADRENAL-GLANDS AND LIVERS OF RATS AND CHICKENS

被引：5
|
作者：
GAY, L [1 ]
EHRICH, M [1 ]
机构：
[1] VIRGINIA MARYLAND REG COLL VET MED,BLACKSBURG,VA 24061
来源：
INTERNATIONAL JOURNAL OF BIOCHEMISTRY | 1990年 / 22卷 / 01期
关键词：
D O I：
10.1016/0020-711X(90)90071-A
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
1. 1. Drug metabolizing enzymes (cytochrome P450, glutathione-S-transferase, carboxylesterase) were compared in livers and adrenal glands from rats and chickens. 2. 2. Quantities of cytochrome P450 in chicken liver and adrenal glands were less than in rat liver and adrenals. 3. 3. Activities of carboxylesterase and of glutathione-S-epoxide transferase were similar in livers of rats and chickens. 4. 4. In the chicken, activities of carboxylesterase and of glutathione-S-epoxide transferase were less in adrenal glands than in livers. 5. 5. Carboxylesterase enzyme activities in adrenal glands of chickens were more sensitive to inhibition by antiesterase agents than were carboxylesterase enzyme activities in liver. © 1990.
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页码：15 / 18
页数：4
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