EFFECT OF POLYSACCHARIDE INTERACTIONS ON ANTIBIOTIC SUSCEPTIBILITY OF PSEUDOMONAS-AERUGINOSA

被引:52
|
作者
ALLISON, DG
MATTHEWS, MJ
机构
[1] Pharmacy Department, Manchester University, Manchester
来源
JOURNAL OF APPLIED BACTERIOLOGY | 1992年 / 73卷 / 06期
关键词
D O I
10.1111/j.1365-2672.1992.tb05009.x
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
The relative viscosity of Pseudomonas aeruginosa alginate was shown to increase markedly when combined with mucin, Ca2+ ions and the exopolysaccharide from Pseudomonas cepacia. The presence of such a heterodisperse polysaccharide solution significantly reduced the diffusion and hence antimicrobial activity of tobramycin and to a lesser extent ciprofloxacin against Ps. aeruginosa by factors of 90 and 2.5-fold respectively over a 5 h incubation period. The clinical implications of these results are discussed in relation to cystic fibrosis.
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页码:484 / 488
页数:5
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