PROTEIN-BINDING AS A COMPONENT OF DRUG-INTERACTION IN CELLULAR PHARMACOKINETIC STUDIES - EFFECTS OF PROBENECID ON TRANSPORT AND ACCUMULATION OF METHOTREXATE IN EHRLICH ASCITES TUMOR-CELLS INVITRO

被引：9

作者：

GEWIRTZ, DA ^{[1
]}

HOLT, SA ^{[1
]}

机构：

[1] VIRGINIA COMMONWEALTH UNIV,MED COLL VIRGINIA,DEPT PHARMACOL,RICHMOND,VA 23298

来源：

BIOCHEMICAL PHARMACOLOGY | 1985年 / 34卷 / 06期

关键词：

D O I：

10.1016/0006-2952(85)90753-1

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

引用

页码：747 / 754

页数：8

共 14 条

[1] PROTEIN-BINDING MODIFIES THE EFFECTS OF PROBENECID ON THE CELLULAR PHARMACOKINETICS OF METHOTREXATE IN THE EHRLICH ASCITES TUMOR-CELL
GEWIRTZ, DA
HOLT, SA
PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH, 1984, 25 (MAR): : 308 - 308
[2] RAPID ACCUMULATION OF METHOTREXATE POLYGLUTAMATES (MTX-PGS) IN EHRLICH ASCITES TUMOR-CELLS INVITRO - MARKED AUGMENTATION BY VINCRISTINE
YALOWICH, JC
FRY, DW
GOLDMAN, ID
PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH, 1981, 22 (MAR): : 207 - 207
[3] ROLE OF METHOTREXATE POLYGLUTAMYLATION AND CELLULAR-ENERGY METABOLISM IN INHIBITION OF METHOTREXATE BINDING TO DIHYDROFOLATE-REDUCTASE BY 5-FORMYLTETRAHYDROFOLATE IN EHRLICH ASCITES TUMOR-CELLS INVITRO
MATHERLY, LH
FRY, DW
GOLDMAN, ID
CANCER RESEARCH, 1983, 43 (06) : 2694 - 2699
[4] EFFECTS OF PH AND CITRATE CONCENTRATIONS ON INVITRO BINDING OF GA-67 TO EHRLICH ASCITES TUMOR-CELLS
SUZUKI, T
OKADA, Y
KOHNO, H
OHKUBO, Y
KUBODERA, A
INTERNATIONAL JOURNAL OF NUCLEAR MEDICINE & BIOLOGY, 1985, 12 (01): : 73 - 74
[5] ACTIONS OF INHALATION ANESTHETICS IN CLINICAL CONCENTRATIONS UPON CELLULAR PROTEIN AND DNA CONTENT OF EHRLICH ASCITES TUMOR-CELLS INVITRO
PANTHONG, A
HACK, G
KARZEL, K
JOURNAL OF THE MEDICAL ASSOCIATION OF THAILAND, 1983, 66 (01): : 27 - 36
[6] RELATIONSHIP AMONG TRANSPORT, INTRACELLULAR BINDING, AND INHIBITION OF RNA-SYNTHESIS BY ACTINOMYCIN-D IN EHRLICH ASCITES TUMOR-CELLS INVITRO
BOWEN, D
GOLDMAN, ID
CANCER RESEARCH, 1975, 35 (11) : 3054 - 3060
[7] EFFECTS OF 2,4-DINITROPHENOL AND OTHER METABOLIC-INHIBITORS ON THE BIDIRECTIONAL CARRIER FLUXES, NET TRANSPORT, AND INTRACELLULAR BINDING OF METHOTREXATE IN EHRLICH ASCITES TUMOR-CELLS
FRY, DW
WHITE, JC
GOLDMAN, ID
CANCER RESEARCH, 1980, 40 (10) : 3669 - 3673
[8] ANALYSIS OF THE INHIBITORY EFFECTS OF VP-16-213 (ETOPOSIDE) AND PODOPHYLLOTOXIN ON THYMIDINE TRANSPORT AND METABOLISM IN EHRLICH ASCITES TUMOR-CELLS INVITRO
YALOWICH, JC
GOLDMAN, ID
CANCER RESEARCH, 1984, 44 (03) : 984 - 989
[9] ANALYSIS OF THE INHIBITORY EFFECTS OF VP-16 AND PODOPHYLLOTOXIN (PDT) ON THYMIDINE (DTHD) TRANSPORT AND METABOLISM IN EHRLICH ASCITES TUMOR-CELLS INVITRO
YALOWICH, JC
GOLDMAN, ID
BACK, N
PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH, 1983, 24 (MAR): : 309 - 309
[10] TENIPOSIDE (VM-26)-INDUCED AND ETOPOSIDE (VP-16-213)-INDUCED AUGMENTATION OF METHOTREXATE TRANSPORT AND POLYGLUTAMYLATION IN EHRLICH ASCITES TUMOR-CELLS INVITRO
YALOWICH, JC
FRY, DW
GOLDMAN, ID
CANCER RESEARCH, 1982, 42 (09) : 3648 - 3653

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