Impact of a high-fat diet on bone health during growth

Background: An inappropriate eating habit is a relatively easily modified risk factor for obesity and osteoporosis in adults. The consumption of high-fat foods is known to induce obesity. Although numerous studies have documented a relationship between high-fat diet (HFD)-induced obesity and osteoporosis, no consensus has been reached. In addition, few data on the relationships between mandibular properties and an HFD in the growth period are available. Objective: This review aims to summarize current findings related to these issues, focusing on the influence of an HFD on mandibular health, including mechanisms of periodontal disease development. Main results: Recent data suggest that HFD-induced obesity has a negative impact on the mandible in mice. The loss of trabecular bone and reduction of cortical bone growth in mice with HFD-induced obesity reflect a state of noninvasive and noninfective inflammation. Authors' conclusions: These results are related to the potential association between metabolic stress and systemic inflammatory changes occurring in bone and other tissues. (C) 2017 Japanese Society of Pediatric Dentistry. Published by Elsevier Ltd. All rights reserved.