EFFECT OF INTERLEUKIN-1-ALPHA ON THE GROWTH OF MYCOBACTERIUM-MICROTI WITHIN J774A.1 CELLS

被引：0
|
作者：
MAJUMDER, S
GUPTA, R
机构：
来源：
FEMS MICROBIOLOGY LETTERS | 1994年 / 120卷 / 03期
关键词：
MYCOBACTERIUM MICROTI; INTERLEUKIN-1-ALPHA; MYCOBACTERIA; CYCLIC AMP;
D O I：
暂无
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The effect of mouse recombinant interleukin-1 alpha on the intracellular growth of Mycobacterium microti in a murine macrophage cell line J774A.1 was investigated. Interleukin-1 alpha added after infection to the M. microti-infected macrophage monolayers enhanced the growth of M. microti in a concentration-dependent manner and this growth enhancement was abrogated by neutralization of interleukin-1 alpha with anti-interleukin-1 alpha antibody. Cyclic adenosine monophosphate level in J774A.1 cells was increased by the addition of interleukin-la. Addition of dibutyryl cyclic adenosine monophosphate to infected J774A.1 cells increased the number of intracellular bacteria in a concentration-dependent manner. These results suggest that interleukin-la acts as a growth enhancer for intracellular M. microti and the growth enhancing effect of interleukin-1 alpha may be due to enhanced cellular cyclic adenosine monophosphate level.
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页码：329 / 334
页数：6
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