HUMAN RETINAL-PIGMENT EPITHELIAL-CELLS POSSESS BETA-2-ADRENERGIC RECEPTORS

被引:13
|
作者
TRAN, VT [1 ]
机构
[1] DOHENY EYE INST,LOS ANGELES,CA 90033
关键词
HUMAN; RETINAL PIGMENT EPITHELIUM; BETA-ADRENERGIC RECEPTORS; ADENYLATE CYCLASE; ICI-118551; BETAXOLOL;
D O I
10.1016/0014-4835(92)90113-7
中图分类号
R77 [眼科学];
学科分类号
100212 ;
摘要
β-adrenergic receptors on cultured human retinal pigment epithelium were demonstrated by the binding of [125I]cyanopindolol. Its pharmacologic specificity was also examined. Specific [125I]cyanopindolol binding was saturable, with a dissociation constant of 130 pm and a receptor density of 12 fmol per one-half million cells, which is equivalent to 14 000 receptor sites per retinal pigment epithelial cell. Agonists competed for specific [125I]cyanopindolol binding, with the following rank order of potencies: (-)-isoproterenol > (-)-epinephrine > (-)-norepinephrine. β2-selective antagonist ICI-118551 was approximately 3 log orders more potent than the β1-selective antagonist, betaxolol. These receptors were also coupled to an adenylate cyclase. These results suggest strongly that cultured human retinal pigment epithelial cells possess β2-adrenergic receptors. The potential significance of these findings with regard to retinal pigment epithelial functions is discussed herein. © 1992.
引用
收藏
页码:413 / 417
页数:5
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