Prospects for Induced Pluripotent Stem Cell-Derived Hepatocytes in Cell Therapy

被引：3

作者：

Iwamuro, Masaya ^{[1
]}

Shahid, Javed M. ^{[2
]}

Yamamoto, Kazuhide ^{[1
]}

Kobayashi, Naoya ^{[2
]}

机构：

[1] Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Gastroenterol & Hepatol, Okayama, Japan

[2] Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Gastroenterol Surg Transplant & Surg Oncol, Okayama, Japan

来源：

CELL MEDICINE | 2011年 / 2卷 / 01期

关键词：

Induced pluripotent stem (iPS) cells; Hepatic differentiation; Hepatocytes;

D O I：

10.3727/215517911X575975

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Induced pluripotent stem (iPS) cells, first established in 2006, have the same characteristics of self-renewability and pluripotency as embryonic stem (ES) cells. iPS cells are inducible from patient-specific somatic cells; therefore, they hold significant advantages for overcoming immunological rejection as well as the ethical issues associated with the derivation of ES cells from embryos. Generation of patient-derived hepatocytes by iPS technology and their use in cell transplantation therapy for patients with liver disease is quite attractive. Here, we discuss recent advances and challenges in hepatocyte differentiation from iPS cells and their utility in cell therapy.

引用

页码：1 / 8

页数：8

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