Pharmacotherapy of Restless Legs Syndrome with Pramipexole

被引:0
|
作者
Merlino, Giovanni [1 ,2 ]
Lorenzut, Simone [1 ]
Sommaro, Martina [1 ]
Gigli, Gian Luigi [1 ,2 ]
Valente, Mariarosaria [1 ,2 ]
机构
[1] Santa Maria della Misericordia Univ Hosp, Dept Neurosci, Sleep Disorders Ctr, Udine, Italy
[2] Univ Udine, DPMSC, Udine, Italy
关键词
restless legs syndrome; pramipexole; dopamine-agonists; augmentation; compulsive behaviors;
D O I
暂无
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Restless Legs Syndrome (RLS) is one of the most common neurological diseases characterized by an urge to move the legs, often associated with unpleasant sensations relieved by movement. It is engendered by rest, and is worse in the evening or at night. Patients affected by severe RLS should be treated pharmacologically. Dopamine-agonists represent the first-line treatment for RLS symptoms. Pramipexole is a non-ergot derived dopamine agonist with a high selectivity for D-2 and D-3 receptors. At doses comprised between 0.125 and 0.75 mg, pramipexole improves subjective symptoms and objective signs of primary RLS even after the first administration. In addition, pramipexole seems to be safe and well tolerated. However, physicians should be aware that augmentation and compulsive behaviours might occur in their RLS patients treated with pramipexole. Further studies are needed to confirm the efficacy of pramipexole in uremic RLS and in children affected by the sleep disorder.
引用
收藏
页码:407 / 415
页数:9
相关论文
共 50 条
  • [1] Pharmacotherapy of Restless Legs Syndrome with Pramipexole
    Manconi, Mauro
    Ferini-Strambi, Luigi
    [J]. CLINICAL MEDICINE INSIGHTS-THERAPEUTICS, 2009, 1 : 1179 - 1188
  • [2] Pramipexole (Mirapex) for restless legs syndrome
    Jarvis, Courtney I.
    Golding, Jeremy
    [J]. AMERICAN FAMILY PHYSICIAN, 2007, 75 (08) : 1239 - 1240
  • [3] Pramipexole (Mirapex) for restless legs syndrome
    不详
    [J]. MEDICAL LETTER ON DRUGS AND THERAPEUTICS, 2007, 49 (1257): : 26 - 28
  • [4] Pramipexole for the treatment of restless legs syndrome
    Kushida, CA
    [J]. EXPERT OPINION ON PHARMACOTHERAPY, 2006, 7 (04) : 441 - 451
  • [5] Pharmacotherapy for restless legs syndrome
    Ferini-Strambi, Luigi
    Marelli, Sara
    [J]. EXPERT OPINION ON PHARMACOTHERAPY, 2014, 15 (08) : 1127 - 1138
  • [6] Efficacy and safety of pramipexole in restless legs syndrome
    Kruszewski, Stefan P.
    Shane, John
    [J]. NEUROLOGY, 2007, 68 (19) : 1641 - 1641
  • [7] Restless legs syndrome augmentation and pramipexole treatment
    Ferini-Strambi, L.
    [J]. SLEEP MEDICINE, 2002, 3 : S23 - S25
  • [8] Efficacy and safety of pramipexole in restless legs syndrome
    Winkelman, J. W.
    Sethi, K. D.
    Kushida, C. A.
    Becker, P. M.
    Koester, J.
    Cappola, J. J.
    Reess, J.
    [J]. NEUROLOGY, 2006, 67 (06) : 1034 - 1039
  • [9] Comparison of Pregabalin with Pramipexole for Restless Legs Syndrome
    Allen, Richard P.
    Chen, Crystal
    Garcia-Borreguero, Diego
    Polo, Olli
    DuBrava, Sarah
    Miceli, Jeffrey
    Knapp, Lloyd
    Winkelman, John W.
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2014, 370 (07): : 621 - 631
  • [10] Pramipexole Alters Thermoregulation in Restless Legs Syndrome
    Salminen, Aaro V.
    Rimpila, Ville
    Polo, Olli
    [J]. JOURNAL OF CLINICAL SLEEP MEDICINE, 2014, 10 (12): : 1325 - 1329