COMPLEMENT C7 M/N ALLOTYPING IN INFECTIOUS-DISEASES

被引：0
|
作者：
WURZNER, R [1 ]
SOLDER, BM [1 ]
PRODINGER, WM [1 ]
DIERICH, MP [1 ]
机构：
[1] UNIV INNSBRUCK, DEPT PAEDIAT, A-6020 INNSBRUCK, AUSTRIA
来源：
EXPERIMENTAL AND CLINICAL IMMUNOGENETICS | 1995年 / 12卷 / 02期
关键词：
COMPLEMENT C7; POLYMORPHISM; HYPOMORPHIC ALLELE; DISEASE ASSOCIATION;
D O I：
暂无
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The allotypes of the C7 M/N polymorphism are determined by ELISA by comparing the reaction pattern of the allospecific monoclonal antibody WU 4-15 with that of polyclonal anti-C7 IgG. In order to find disease associations of the two alleles C7*M and C7*N we tested 528 hospitalised patients, most of them suffering from infectious diseases. No significant association of either of the two C7 M/N alleles to a particular disease was found, in particular refuting the hypothesis that Lyme borreliosis may be more frequent in homozygous carriers of the hypomorphic allele C7*N.
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页码：61 / 65
页数：5
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