PREPARATION OF HIGH-MOLECULAR-WEIGHT RADIOIODINATED ALGINIC ACID

被引：3
|
作者：
ORLANDO, P [1 ]
BINAGLIA, L [1 ]
DEFEO, A [1 ]
TREVISI, R [1 ]
MELODIA, C [1 ]
TRENTA, R [1 ]
机构：
[1] UNIV PERUGIA,FAC MED & CHIRURG,IST BIOCHIM & CHIM MED,I-06100 PERUGIA,ITALY
来源：
JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS | 1994年 / 34卷 / 07期
关键词：
I-125; TYRAMINE; GLYCURONANS; ALGINIC ACID; LABELING;
D O I：
10.1002/jlcr.2580340709
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
A simple procedure is described for preparing I-125-labelled alginic acid. The reducing terminal of alginic acid is derivatized with tyramine through the formation of Schiff base which is subsequently reduced with sodium cyanoborohydride. By radioiodination of the aromatic ring introduced, I-125-labelled alginic acid was obtained with high specific activity.
引用
收藏
页码：653 / 657
页数：5
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