DIFFERENTIAL BINDING OF TIOCONAZOLE ENANTIOMERS TO HYDROXYPROPYL-BETA-CYCLODEXTRIN STUDIED BY CAPILLARY ELECTROPHORESIS

被引：129
|
作者：
PENN, SG
GOODALL, DM
LORAN, JS
机构：
[1] UNIV YORK,DEPT CHEM,YORK YO1 5DD,N YORKSHIRE,ENGLAND
[2] PFIZER LTD,CENT RES,SANDWICH CT13 9NJ,KENT,ENGLAND
来源：
JOURNAL OF CHROMATOGRAPHY | 1993年 / 636卷 / 01期
关键词：
D O I：
10.1016/0021-9673(93)80067-I
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
Capillary electrophoresis has been used to determine binding constants of tioconazole enantiomers with hydroxypropyl-beta-cyclodexrin (HP-beta-CD), after correcting for changes in mobility with increasing viscosity. The predicted and observed values of enantiomeric mobility difference were found to be maximum at a concentration of HP-beta-CD equal to the reciprocal of the average binding constant.
引用
收藏
页码：149 / 152
页数：4
相关论文
共 50 条
  • [1] A study of the interaction between enantiomers of zolmitriptan and hydroxypropyl-beta-cyclodextrin by capillary electrophoresis
    Pang, Nannan
    Zhang, Zhengxiang
    Bai, Yu
    Liu, Huwei
    [J]. ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 2009, 393 (01) : 313 - 320
  • [2] A study of the interaction between enantiomers of zolmitriptan and hydroxypropyl-beta-cyclodextrin by capillary electrophoresis
    Nannan Pang
    Zhengxiang Zhang
    Yu Bai
    Huwei Liu
    [J]. Analytical and Bioanalytical Chemistry, 2009, 393 : 313 - 320
  • [3] THE BINDING OF ALKYL CHAINS TO BETA-CYCLODEXTRIN AND HYDROXYPROPYL-BETA-CYCLODEXTRIN
    TEE, OS
    GADOSY, TA
    GIORGI, JB
    [J]. JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 2, 1993, (10): : 1705 - 1706
  • [4] Enantiomeric separation of amphetamine and phenylephrine by capillary zone electrophoresis with hydroxypropyl-beta-cyclodextrin as chiral additive
    Wang, Z
    Huang, AJ
    Sun, YL
    Sun, ZP
    [J]. HRC-JOURNAL OF HIGH RESOLUTION CHROMATOGRAPHY, 1997, 20 (05): : 298 - 299
  • [5] EFFECTS OF PH AND HYDROXYPROPYL-BETA-CYCLODEXTRIN CONCENTRATION ON PEAK RESOLUTION IN THE CAPILLARY ELECTROPHORETIC SEPARATION OF THE ENANTIOMERS OF WEAK BASES
    RAWJEE, YY
    WILLIAMS, RL
    BUCKINGHAM, LA
    VIGH, G
    [J]. JOURNAL OF CHROMATOGRAPHY A, 1994, 688 (1-2) : 273 - 282
  • [6] SAFETY OF PARENTERAL HYDROXYPROPYL-BETA-CYCLODEXTRIN
    CARPENTER, TO
    GERLOCZY, A
    PITHA, J
    [J]. JOURNAL OF PHARMACEUTICAL SCIENCES, 1995, 84 (02) : 222 - 225
  • [7] COMPLEXATION OF HYDROCORTISONE WITH BETA-CYCLODEXTRIN AND HYDROXYPROPYL-BETA-CYCLODEXTRIN
    PREISS, A
    MEHNERT, W
    FROMMING, KH
    [J]. ARCHIV DER PHARMAZIE, 1994, 327 (11) : 729 - 734
  • [8] THE PHARMACOKINETICS OF BETA-CYCLODEXTRIN AND HYDROXYPROPYL-BETA-CYCLODEXTRIN IN THE RAT
    FRIJLINK, HW
    VISSER, J
    HEFTING, NR
    OOSTING, R
    MEIJER, DKF
    LERK, CF
    [J]. PHARMACEUTICAL RESEARCH, 1990, 7 (12) : 1248 - 1252
  • [9] INCLUSION COMPLEXES OF TOLNAFTATE WITH BETA-CYCLODEXTRIN AND HYDROXYPROPYL-BETA-CYCLODEXTRIN
    PERI, D
    WYANDT, CM
    CLEARY, RW
    HIKAL, AH
    JONES, AB
    [J]. DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, 1994, 20 (08) : 1401 - 1410
  • [10] Solubilizing coelenterazine in water with hydroxypropyl-beta-cyclodextrin
    Teranishi, K
    Shimomura, O
    [J]. BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 1997, 61 (07) : 1219 - 1220
12345