PAN MASALA - A GENOTOXIC MENACE

被引：15
|
作者：
PATEL, RK
JAJU, RJ
BAKSHI, SR
TRIVEDI, AH
DAVE, BJ
ADHVARYU, SG
机构：
[1] GUJARAT CANC SOC,DIV CELL BIOL,AHMEDABAD 380016,GUJARAT,INDIA
[2] GUJARAT CANC RES INST,AHMEDABAD 380016,GUJARAT,INDIA
来源：
MUTATION RESEARCH | 1994年 / 320卷 / 03期
关键词：
PAN MASALA; CHROMOSOME ABERRATION; SISTER-CHROMATID EXCHANGE; MICRONUCLEATED CELLS; DMSO EXTRACT; METABOLIC ACTIVATION;
D O I：
10.1016/0165-1218(94)90051-5
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Cytogenetic markers such as chromosome aberration (CA), sister-chromatid exchange (SCE) and micronucleated cells (MNC) were used to assess the genotoxic potential of dimethyl sulphoxide (DMSO) extract of pan masala with and without tobacco (PM-T and PM). Using in vitro short-term assays, the extracts were tested in the presence or absence of metabolic activation. In cultures without metabolic activation the extracts were found to increase the frequency of all the three parameters tested significantly, however those with activation elicited a weak response, implying that pan masalas contain solvent (DMSO)-soluble direct-acting mutagen.
引用
收藏
页码：245 / 249
页数：5
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