SYNTHESIS AND ANTIPLATELET ACTIVITY OF SOME 1,8-NAPHTHYRIDINE DERIVATIVES

被引：13
|
作者：
FERRARINI, PL
MORI, C
MICELI, M
FRANCONI, F
机构：
[1] OSPED ANNUNZIATA,ANAL MED LAB,I-50011 FLORENCE,ITALY
[2] UNIV SASSARI,FAC FARM,IST CHIM BIOL,I-07100 SASSARI,ITALY
来源：
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 1994年 / 29卷 / 10期
关键词：
1,8-NAPHTHYRIDINE; INHIBITION OF PLATELET AGGREGATION; HUMAN BLOOD PLATELETS; PIPERIDINE; DIETHANOLAMINE;
D O I：
10.1016/0223-5234(94)90131-7
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A series of 1,8-naphthyridine derivatives was synthesized and tested for their ability to inhibit human platelet aggregation in vitro induced by arachidonic acid, collagen and ADP. Some compounds showed remarkable activity and the most active derivatives were comparable to papaverine in the test with arachidonic acid and collagen. In the test with ADP the tested compounds showed no significant activity. The tested compounds that possessed the best activity were also demonstrated to increase the c-AMP level significantly without involving the adenylyl cyclase system.
引用
收藏
页码：735 / 741
页数：7
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