DURATION OF ANTIHYPERTENSIVE EFFECTIVENESS DURING THERAPY WITH CICLETANINE IN AMBULATORY 24-H BLOOD-PRESSURE MEASUREMENT

The duration of the effect of a once-daily dose of cicletanine was investigated over an 8-week period in a double-blind placebo-controlled study in 39 patients with mild to moderate hypertension. Under treatment with 100 mg cicletanine each morning, a clear reduction in blood pressure, more marked in the day than in the night, was seen. Therefore, an effective reduction of blood pressure was seen without altering the diurnal profile (circadian rhythm).