THE INFLUENCE OF PHENFORMIN AND SUCCINIC ACID UPON TRANS-PLACENTAL CARCINOGENIC EFFECT OF N-ETHYL-N-NITROSOUREA IN RATS

被引：0
|
作者：
BESPALOV, VG
ALEXANDROV, VA
机构：
来源：
VOPROSY ONKOLOGII | 1984年 / 30卷 / 10期
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D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The influence of a long-term postnatal treatment with an antidiabetic biguanide, phenformin and a biologic stimulating agent, succinic acid upon the realization of transplacental carcinogenic effect of N-ethy-N-nitrosourea (ENU) in rats. Phenformin treatment inhibited the development of induced tumors in the nervous system and kidneys, significantly decreased the total incidence and multiplicity of these tumors, and the incidence of brain and spinal cord tumors and multiplicity of brain tumors. Succinic acid did not influence the transplacental carcinogenic effect of ENU.
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页码：55 / 59
页数：5
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