A GLYCEROL ETHER INDUCES MOBILIZATION AND 12-LIPOXYGENATION OF ARACHIDONIC-ACID IN MACROPHAGES - SYNERGISTIC EFFECT ON MOBILIZATION AND INDUCTION OF LEUKOTRIENE-C FORMATION BY ACTIVATORS OF PROTEIN KINASE-C

被引：2
|
作者：
SUNDLER, R
EMILSSON, A
WIJKANDER, J
机构：
[1] Department of Medical and Physiological Chemistry, University of Lund, Lund, S-221 00
来源：
AGENTS AND ACTIONS | 1990年 / 29卷 / 3-4期
关键词：
D O I：
10.1007/BF01966454
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A glycerol triether, 1,2-isopropylidene 3-0-decanyl-sn-glycerol, was found to induce mobilization of archidonic acid from ethanolamine phosphoglycerides and phosphatidylinositol in mouse peritoneal macrophages. This effect showed structural specificity, occurred without activation of protein kinase C and resulted in formation and release of predominantly 12-hydroxy-eicosatetraenoic acid. Activators of kinase C (4-β-phorbol 12-myristate 13-acetate and 1,2-dioctanoyl-sn-glycerol) instead specifically enhance prostaglandin E2 formation. When macrophages were exposed to both a kinase C activator and the glycerol triether, the mobilization of arachidonic acid was synergistically enhanced and formation of leukotriene C was induced. © 1990 Birkhäuser Verlag.
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页码：247 / 253
页数：7
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