Homocysteine levels in patients with obstructive sleep apnea syndrome

被引：0
|
作者：
Yavuz, Zekiye [1 ]
Ursavas, Ahmet [1 ]
Ege, Ercument [1 ]
Ilcol, Yesim Ozarda [2 ]
Karadag, Mehmet [1 ]
Uzaslan, Esra [1 ]
Gozu, R. Oktay [1 ]
机构：
[1] Uludag Univ, Fac Med, Dept Chest Dis, Bursa, Turkey
[2] Uludag Univ, Fac Med, Dept Biochem, Bursa, Turkey
来源：
TUBERKULOZ VE TORAK-TUBERCULOSIS AND THORAX | 2008年 / 56卷 / 01期
关键词：
Obstructive sleep apnea; homocysteine;
D O I：
暂无
中图分类号：
R56 [呼吸系及胸部疾病];
学科分类号：
摘要：
The exact mechanism of development of cardiovascular disease in patients with obstructive sleep apnea syndrome (OSAS) remains to be unknown. The role of homocystein in atherosclerotic disease process has become well established over the past ten years. Our aim was to study to compare homoscysteine levels between OSAS and control levels. Sixty-two subjects with OSAS and twelve similar controls in age, gender, body mass index, smoking and coronary heart disease were included in this prospective study. Serum levels of homocysteine (13.5 +/- 6.0 mu mol/L vs. 10.2 +/- 2.9 mu mol/L, p= 0.03) in the OSAS group were significantly greater than those in the control group. Logistic regression analyses showed that OSAS ( Odds ratio: 9.08 95% CI 2.347-35.120; p= 0.001) was independent risk factors for high levels of serum homocysteine in age, smoking status, diabetes mellitus and coronary heart disease. We conclude that homocysteine may be an important factor for development of cardiovascular disease in patients with OSAS.
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页码：37 / 42
页数：6
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