The Clinicopathological Study of Lupus Nephritis

Purpose: Lupus nephritis is one of the most serious manifestations of Systemic lupus erythematosis and it is a major cause of morbidity and mortality. The aim of this study is to compare males and females in lupus nephritis presentations. Material and Methods: A cross-sectional study performed on forty five patients with biopsy proven Lupus Nephritis including 32 females and 13 males. All patients assessed by questionnaire form and investigated for hematological, biochemical, immunological, serological, urinalysis, and 24hrs urinary protein excretion. Results: The current study shows female predominance 32(71.1%) compared with 13(28.9%) male. Class IV 15(33.3%) nephritis was the most common type followed by class III 9(20.9%). The male patients develop nephritis early in the course of Systemic lupus erythematosis than females, and they were more commonly had hypertension and edema, and the hematological, cardiovascular, pulmonary, and central nervous system were the most common extra renal manifestation in males while mucocutaneous manifestations were the commonest in females, and further more males had more proliferative type of Lupus nephritis than females. Conclusion: Males had more severe type of lupus nephritis than females.