AMINOTRIAZOLE IS A POTENT INHIBITOR OF ALPHA-OXIDATION OF 3-METHYL-SUBSTITUTED FATTY-ACIDS IN RAT-LIVER

被引：30
|
作者：
CASTEELS, M [1 ]
CROES, K [1 ]
VANVELDHOVEN, PP [1 ]
MANNAERTS, GP [1 ]
机构：
[1] CATHOLIC UNIV LEUVEN,B-3000 LOUVAIN,BELGIUM
来源：
BIOCHEMICAL PHARMACOLOGY | 1994年 / 48卷 / 10期
关键词：
AMINOTRIAZOLE; PEROXISOMES; CATALASE; FORMATE; ALPHA-OXIDATION; PHYTANIC ACID;
D O I：
10.1016/0006-2952(94)90596-7
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The production of CO2 and formate in isolate rat hepatocytes incubated in the presence of 3-methyl[1-C-14]margaric acid was investigated. Production rates of formate were approximately 4-fold lower than those of CO2. Aminotriazole (3-amino-1, 2, 4-triaxole), an irreversible inhibitor of catalase, potently suppressed alpha-oxidation of 3-methylmargaric acid, whereas beta-oxidation of palmitate, 2-methylpalmitate and trihydroxycoprostanic acid and conversion of exogenously added formate to CO2 were not or only slightly affected. This shows that aminotriazole is not only an inhibitor of catalase, but also of alpha-oxidation of 3-methyl-substituted fatty acids.
引用
收藏
页码：1973 / 1975
页数：3
相关论文
共 50 条
  • [1] ALPHA-OXIDATION OF 3-METHYL-SUBSTITUTED FATTY-ACIDS IN RAT-LIVER
    HUANG, S
    VANVELDHOVEN, PP
    VANHOUTTE, F
    PARMENTIER, G
    EYSSEN, HJ
    MANNAERTS, GP
    ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1992, 296 (01) : 214 - 223
  • [2] EVIDENCE FOR THE IMPORTANCE OF IRON IN THE ALPHA-OXIDATION OF 3-METHYL-SUBSTITUTED FATTY-ACIDS IN THE INTACT CELL
    CROES, K
    CASTEELS, M
    VANVELDHOVEN, PP
    MANNAERTS, GP
    BIOCHIMICA ET BIOPHYSICA ACTA-LIPIDS AND LIPID METABOLISM, 1995, 1255 (01): : 63 - 67
  • [3] Alpha-oxidation of 3-methyl-substituted fatty acids and its thiamine dependence
    Casteels, M
    Foulon, V
    Mannaerts, GP
    Van Veldhoven, PP
    EUROPEAN JOURNAL OF BIOCHEMISTRY, 2003, 270 (08): : 1619 - 1627
  • [4] ALPHA-OXIDATION OF FATTY-ACIDS IN ESCHERICHIA-COLI
    LEKAKIS, NJ
    FEMS MICROBIOLOGY LETTERS, 1977, 1 (05) : 289 - 292
  • [5] ACTIVATION OF 3-METHYL-BRANCHED FATTY-ACIDS IN RAT-LIVER
    VANHOOREN, JCT
    ASSELBERGHS, S
    EYSSEN, HJ
    MANNAERTS, GP
    VANVELDHOVEN, PP
    INTERNATIONAL JOURNAL OF BIOCHEMISTRY, 1994, 26 (09): : 1095 - 1101
  • [6] ALPHA-OXIDATION OF FATTY-ACIDS IN FASTED OR DIABETIC RATS
    TAKAHASHI, T
    TAKAHASHI, H
    TAKEDA, H
    SHICHIRI, M
    DIABETES RESEARCH AND CLINICAL PRACTICE, 1992, 16 (02) : 103 - 108
  • [7] INHIBITION OF ALPHA-KETOGLUTARATE OXIDATION BY FATTY-ACIDS IN RAT-LIVER MITOCHONDRIA
    LENARTOWICZ, E
    OLSON, MS
    JOURNAL OF BIOLOGICAL CHEMISTRY, 1978, 253 (17) : 5990 - 5996
  • [8] MITOCHONDRIAL BETA-OXIDATION OF 2-METHYL FATTY-ACIDS IN RAT-LIVER
    MAO, LF
    CHU, CH
    LUO, MJ
    SIMON, A
    ABBAS, AS
    SCHULZ, H
    ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1995, 321 (01) : 221 - 228
  • [9] ALPHA-OXIDATION OF ENDOGENOUS FATTY-ACIDS IN FRESH POTATO SLICES
    LATIES, GG
    JACOBSON, BS
    HOELLE, C
    PHYTOCHEMISTRY, 1972, 2 (12) : 3403 - &
  • [10] PHYTANIC ACID ALPHA-OXIDATION IN RAT-LIVER MITOCHONDRIA
    PAHAN, K
    GULATI, S
    SINGH, I
    BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 1994, 1201 (03): : 491 - 497
12345