SYNTHESIS OF 5-SUBSTITUTED PYRIMIDINES - ORTHO-DIRECTED LITHIATION OF PYRIMIDINE-DERIVATIVES

被引：22
|
作者：
WADA, A
YAMAMOTO, J
HAMAOKA, Y
OHKI, K
NAGAI, S
KANATOMO, S
机构：
[1] School of Pharmacy, Hokuriku University, Kanazawa, 920-11, Ho‐3, Kanagawa‐machi
来源：
JOURNAL OF HETEROCYCLIC CHEMISTRY | 1990年 / 27卷 / 06期
关键词：
D O I：
10.1002/jhet.5570270658
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
ortho‐Directed lithiation of some pyrimidines has been investigated. Treatment of 2‐ and/or 4‐alkoxy or acylaminopyrimidine with lithium 2,2,6,6‐tetramethylpiperidide in ether at 0°, followed by quenching with various electrophiles afforded the corresponding 5‐substituted pyrimidines. Copyright © 1990 Journal of Heterocyclic Chemistry
引用
收藏
页码：1831 / 1835
页数：5
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