CLINICAL PRACTICE GUIDELINE: CYP2D6 GENOTYPING FOR SAFE AND EFFICACIOUS CODEINE THERAPY

被引：0

作者：

Madadi, Parvaz ^{[1
]}

Amstutz, Ursula ^{[2
,3
,4
]}

Rieder, Michael ^{[5
,6
,7
]}

Ito, Shinya ^{[1
]}

Fung, Vincent ^{[8
,9
,10
,11
]}

Hwang, Soomi ^{[3
,4
,5
,6
,7
,8
,9
]}

Turgeon, Jacques ^{[12
,13
]}

Michaud, Veronique ^{[12
,13
]}

Koren, Gideon ^{[1
,5
,6
,7
]}

Carleton, Bruce C. ^{[2
,3
,4
]}

机构：

[1] Hosp Sick Children, Div Clin Pharmacol & Toxicol, Dept Pediat, Toronto, ON, Canada

[2] Univ British Columbia, Div Translat Therapeut, Dept Pediat, Vancouver, BC, Canada

[3] BC Childrens Hosp, Pharmaceut Outcomes Programme, Vancouver, BC, Canada

[4] Child & Family Res Inst, Vancouver, BC, Canada

[5] Univ Western Ontario, Schulich Sch Med & Dent, Dept Med, Clin Pharmacol, London, ON, Canada

[6] Univ Western Ontario, Schulich Sch Med & Dent, Dept Physiol & Pharmacol, London, ON, Canada

[7] Univ Western Ontario, Schulich Sch Med & Dent, Dept Pediat, London, ON, Canada

[8] Prohlth Clin Res Ctr, Vancouver, BC, Canada

[9] Univ British Columbia, Fac Pharmaceut Sci, Vancouver, BC, Canada

[10] Univ British Columbia, Fac Med, Dept Family Med, Vancouver, BC, Canada

[11] Univ British Columbia, Fac Med, Dept Pathol & Lab Med, Vancouver, BC, Canada

[12] Ctr Hosp Univ Montreal, Univ Montreal Hosp Ctr CRCHUM, Res Ctr, Montreal, PQ, Canada

[13] Univ Montreal, Fac Pharm, Montreal, PQ, Canada

来源：

JOURNAL OF POPULATION THERAPEUTICS AND CLINICAL PHARMACOLOGY | 2013年 / 20卷 / 03期

基金：

加拿大健康研究院;

关键词：

Codeine; morphine; pharmacogenetics; CYP2D6; guidelines;

D O I：

暂无

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

This guideline is intended to provide a basis for informed decision-making regarding genetic testing to identify those individuals who will not benefit from codeine therapy, as well as those who are at an increased risk for codeine-induced toxicity. This guideline addresses the following key questions: 1) Should genetic testing for CYP2D6 be performed in patients prior to the initiation of codeine therapy? 2) How should patients with an indication for codeine therapy be managed based on their genotyping results for CYP2D6?

引用

页码：E369 / E396

页数：28

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