SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF IMMOBILIZED QUATERNARY AMMONIUM-SALTS

被引：40
|
作者：
AUGUSTA, S
GRUBER, HF
STREICHSBIER, F
机构：
[1] VIENNA TECH UNIV,INST CHEM TECHNOL ORGAN MAT,GETREIDEMARKT 9,A-1060 VIENNA,AUSTRIA
[2] VIENNA TECH UNIV,INST BIOCHEM TECHNOL & MICROBIOL,A-1060 VIENNA,AUSTRIA
来源：
JOURNAL OF APPLIED POLYMER SCIENCE | 1994年 / 53卷 / 09期
关键词：
D O I：
10.1002/app.1994.070530903
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
Quaternary ammonium salts were immobilized on hydrophilic gels based on sucrose methacrylates (SM) and tested for their antibacterial properties. The cross-linked polymers were prepared by copolymerization of monomer-SM mixtures with 4-vinylpyridine and subsequent quaternization with 1-bromoctane and 1-bromoctadecan and by esterification of SM gels with 3-pyridine carboxylic acid chloride and quaternization. In addition, immobilized quaternary salts bonded by hydrophobic as well as by hydrophilic spacers were synthesized by esterification of SM gels with 11-bromundecanoic acid chloride and the tetraethylene glycol-based acid chloride 13c, respectively, and subsequent reaction of the halogen-substituted gels with tertiary amines. Suspension tests for antibacterial properties of the immobilized bactericides against Escherichia coli, Staphylococcus aureus, and Micrococcus luteus demonstrated high activity of the quaternary salts bonded by the hydrophobic spacer. Advantageously, these insoluble bactericides can be applicated without contamination of the substrate; they can be removed easily and used repeatedly. (C) 1994 John Wiley & Sons, Inc.
引用
收藏
页码：1149 / 1163
页数：15
相关论文
共 50 条
  • [1] METHOD FOR SYNTHESIS OF QUATERNARY AMMONIUM-SALTS
    KOTLYAREVSKII, IL
    TKACHEVA, NA
    [J]. BULLETIN OF THE ACADEMY OF SCIENCES OF THE USSR DIVISION OF CHEMICAL SCIENCE, 1974, 23 (12): : 2721 - 2722
  • [2] ANTIBACTERIAL ACTIVITY OF NEW SYNTHESIZED AMINO-OXIDES AND QUATERNARY AMMONIUM-SALTS
    CUPKOVA, V
    ESPERSEN, F
    HOIBY, N
    [J]. ZENTRALBLATT FUR HYGIENE UND UMWELTMEDIZIN, 1990, 190 (04): : 404 - 411
  • [3] SYNTHESIS AND ANTIBACTERIAL EFFECT OF SURFACTANT QUATERNARY AMMONIUM-SALTS CONTAINING OXYETHYL RADICALS
    LIMANOV, VE
    EPSHTEIN, AE
    SKVORTSOVA, EK
    AREFEVA, LI
    GLEIBERMAN, SE
    VOLKOVA, AP
    [J]. KHIMIKO-FARMATSEVTICHESKII ZHURNAL, 1976, 10 (01): : 63 - 66
  • [4] SYNTHESIS, LIPOPHILICITY STUDIES AND ANTIBACTERIAL PROPERTIES OF SOME NOVEL QUATERNARY AMMONIUM-SALTS
    SIATRAPAPASTAIKOUDI, T
    PAPADAKIVALIRAKI, A
    TSANTILIKAKOULIDOU, A
    TZOUVELEKIS, L
    MENTIS, A
    [J]. CHEMICAL & PHARMACEUTICAL BULLETIN, 1994, 42 (02) : 392 - 394
  • [5] COMPARATIVE BACTERICIDAL ACTIVITY OF QUATERNARY AMMONIUM-SALTS
    TSVIROVA, IM
    KRUCHENOK, TB
    EPSHTEIN, AE
    GLEIBERMAN, SE
    GORIN, SV
    TSETLIN, VM
    [J]. KHIMIKO-FARMATSEVTICHESKII ZHURNAL, 1984, 18 (10): : 1218 - 1224
  • [6] SYNTHESIS AND PHARMACOLOGICAL ACTIVITY OF SEVERAL PYRROLINDOLE AND BISINDOLE QUATERNARY AMMONIUM-SALTS
    SAMSONIYA, SA
    MEDVEDEV, BA
    KADZHRISHVILI, DO
    TABIDZE, DM
    MASHKOVSKY, MD
    SUVOROV, NN
    [J]. KHIMIKO-FARMATSEVTICHESKII ZHURNAL, 1982, 16 (11): : 1335 - 1338
  • [7] SYNTHESIS AND PHARMACOLOGICAL ACTIVITY OF BIS-INDOL QUATERNARY AMMONIUM-SALTS
    CHIKVAIDZE, IS
    MEDVEDEV, BA
    SAMSONIYA, SA
    MASHKOVSKY, MD
    SUVOROV, NN
    [J]. KHIMIKO-FARMATSEVTICHESKII ZHURNAL, 1980, 14 (05): : 36 - 39
  • [8] QUATERNARY AMMONIUM AMALGAMS AS ZINTL ION SALTS AND THEIR USE IN THE SYNTHESIS OF NOVEL QUATERNARY AMMONIUM-SALTS
    GARCIA, E
    COWLEY, AH
    BARD, AJ
    [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1986, 108 (19) : 6082 - 6083
  • [9] QUATERNARY AMMONIUM-SALTS OF HEPTACAINE
    CIZMARIK, J
    MAZAN, S
    SVEC, P
    BOROVANSKY, A
    [J]. PHARMAZIE, 1978, 33 (11): : 762 - 763
  • [10] QUATERNARY AMMONIUM-SALTS OF POTENTIAL BIOLOGICAL-ACTIVITY
    BADAWI, AM
    ELMARZIBANI, MM
    HAROUN, B
    SOLIMAN, H
    [J]. CURRENT SCIENCE, 1983, 52 (24): : 1169 - 1171
12345