Immunotherapy for Melanoma

Melanoma represents an immunogenic tumour who can be recognized and destroyed by the immune system. This antitumour immunity is not only mediated by T cells but also by B cells and NK cells. Due to continuous research on the molecular mechanisms underlying the interactions between tumour cells and immune cells new immunotherapeutic approaches are further optimized. However, a significant clinical benefit for patients still needs to be achieved. Better selection of patients, who might respond to immunotherapy by determing the HLA status and the antigen expression profile of the tumor might help to overcome the therapeutic resistance of melanoma.