iPS Cells for Modelling and Treatment of Retinal Diseases

被引：22

作者：

Chen, Fred K. ^{[1
,2
]}

McLenachan, Samuel ^{[1
]}

Edel, Michael ^{[3
,4
,5
,6
]}

Da Cruz, Lyndon ^{[7
,8
]}

Coffey, Peter J. ^{[8
]}

Mackey, David A. ^{[1
]}

机构：

[1] Univ Western Australia, Ctr Ophthalmol & Visual Sci, Incorporating Lions Eye Inst, Perth, WA 6009, Australia

[2] Royal Perth Hosp, Ophthalmol Dept, Perth, WA 6009, Australia

[3] Univ Barcelona, Hosp Clin, Fac Med, Dept Physiol Sci 1,Control Pluripotency Lab, Barcelona 08036, Spain

[4] Univ Western Australia, Sch Med & Pharmacol, Perth, WA 6009, Australia

[5] Univ Sydney, Westmead Childrens Hosp, Fac Med, Med Sch,Div Paediat & Child Hlth, Sydney, NSW 2145, Australia

[6] Victor Chang Cardiac Res Inst, Dev & Stem Cell Biol, Sydney, NSW 2145, Australia

[7] Moorfields Eye Hosp, Dept Vitreoretinal Surg, London EC1V 2PD, England

[8] UCL, Inst Ophthalmol, Div Cellular Therapy, London EC1V 9EL, England

来源：

JOURNAL OF CLINICAL MEDICINE | 2014年 / 3卷 / 04期

关键词：

age-related macular degeneration; inherited retinal disease; retinal dystrophy; macular dystrophy; retina; induced pluripotent; stem cells; cell transplantation; disease modelling; genetic diagnosis;

D O I：

10.3390/jcm3041511

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

For many decades, we have relied on immortalised retinal cell lines, histology of enucleated human eyes, animal models, clinical observation, genetic studies and human clinical trials to learn more about the pathogenesis of retinal diseases and explore treatment options. The recent availability of patient-specific induced pluripotent stem cells (iPSC) for deriving retinal lineages has added a powerful alternative tool for discovering new disease-causing mutations, studying genotype-phenotype relationships, performing therapeutics-toxicity screening and developing personalised cell therapy. This review article provides a clinical perspective on the current and potential benefits of iPSC for managing the most common blinding diseases of the eye: inherited retinal diseases and age-related macular degeneration.

引用

页码：1511 / 1541

页数：31

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