We present, based upon quantum electrodynamics in Robertson-Walker flat universes, a thorough analysis of the creation of mutually interacting electron-positron pairs and photons from vacuum. Therefore we discuss at least qualitatively all processes contributing to the number densities of created particles up to the second order in the coupling constant. For two particular expansion laws with Minkowskian in respectively in and out regions, we obtain exact solutions to the Dirac equation and investigate in detail the process of simultaneous creation of electron-positron pairs and photons and the related attenuation effect for fermionic particles. This is done for electrons and positrons which have nonrelativistic momenta at Compton time in rapidly expanding universes. The results are compared with the zeroth-order creation of electron-positron pairs. Despite being smaller by a factor of roughly e0(2)/4-pi almost-equal-to 1/137, the interacting-particle creation is important mainly as a source of photons even in conformally flat universes.