IMPROVEMENT OF DISSOLUTION RATE OF POORLY SOLUBLE ALPRAZOLAM BY SOLID DISPERSION

被引：0
|
作者：
Manna, Niranjan Kumar [1 ]
Roul, Laxmikanta [1 ]
机构：
[1] Coll Pharmaceut Sci, Dept Pharmaceut, Berhampur 760002, Orissa, India
来源：
INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES AND RESEARCH | 2011年 / 2卷 / 01期
关键词：
Alprazolam; Solid dispersion; Carriers; Polyethylene glycol 6000; Polyvinyl pyrrolidone k-30;
D O I：
10.13040/IJPSR.0975-8232.2(1).79-83
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Dissolution rate enhancement of alprazolam, an anti-anxiety drug, was done by preparing solid dispersions by solvent evaporation method. Polyethylene glycol 6000 and Polyvinyl pyrrolidone k-30 were selected as carriers. Drug: Polymer ratios were taken as 1:1,1:2and1:4 for both the polymers for the preparation of solid dispersions. Tablets were prepared from solid dispersions and also from physical mixtures by direct compression. Dissolution rates and drug releases of solid dispersions or their tablets were found more than those of corresponding physical mixtures or their tablets.
引用
收藏
页码：79 / 83
页数：5
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