DUAL ACTION OF CLONIDINE ON ETHANOL-INDUCED GASTRIC-LESIONS - IS THE IMIDAZOLINE-PREFERRING RECEPTOR INVOLVED

被引:17
|
作者
BHANDARE, PN
RATABOLI, PV
DSOUZA, RSD
机构
关键词
ETHANOL LESION; CLONIDINE; ALPHA-2-ADRENOCEPTORS; IMIDAZOLINE PREFERRING RECEPTOR;
D O I
10.1016/0014-2999(91)90464-2
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The imidazole alpha-2-adrenoceptor agonist, clonidine, exerts a dual action on ethanol-induced gastric lesions. At lower doses, it has a gastroprotective effect which is also seen with two other alpha-2-adrenoceptor agonists - the catecholamine, alpha-methyldopa and the guanidine, guanabenz. The gastroprotective action of the three drugs is prevented by the selective alpha-2-adrenoceptor antagonist, yohimbine, suggesting that the action is mediated by alpha-2-adrenoceptors. However, at higher doses clonidine aggravates ethanol-induced gastric lesions, an effect also seen with another imidazole, oxymetazoline. The aggravating action is not prevented by yohimbine and is not seen with alpha-methyldopa and guanabenz. This suggests that it involves a receptor/mechanism other than alpha-2 - possibly an imidazoline-preferring receptor but further work, including radioligand binding studies, is needed to confirm this.
引用
收藏
页码:243 / 245
页数:3
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