CHANGES IN HOMEOBOX-CONTAINING GENE-EXPRESSION DURING ECTOPIC BONE-FORMATION INDUCED BY BONE MORPHOGENETIC PROTEIN

被引：29
|
作者：
IIMURA, T
OIDA, S
TAKEDA, K
MARUOKA, Y
SASAKI, S
机构：
[1] TOKYO MED & DENT UNIV, FAC DENT, DEPT ORAL & MAXILLOFACIAL SURG 1, BUNKYO KU, TOKYO 113, JAPAN
[2] TOKYO MED & DENT UNIV, FAC DENT, DEPT ORAL & MAXILLOFACIAL SURG 2, BUNKYO KU, TOKYO 113, JAPAN
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1994年 / 201卷 / 02期
关键词：
D O I：
10.1006/bbrc.1994.1798
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Expression of homeobox genes in relation to ectopic bone formation induced by bone morphogenetic protein (BMP) was investigated. Oligonucleotide primers corresponding to highly conserved regions of Hox cluster and Msx genes were designed to detect homeobox sequences by means of the polymerase chain reaction (PCR). Nine rat homologues of Hox duster genes and two Msx genes were discovered in the BMP-implanted tissue, at earlier stage and later cartilage and bone formation stage, respectively. The PCR study provided evidence of dynamic changes in BMP-induced homeobox gene expression. (C) 1994 Academic Press, Inc.
引用
收藏
页码：980 / 987
页数：8
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