THE PALLADIUM-CATALYZED CROSS-COUPLING REACTION OF ENOL ACETATES OF ALPHA-BROMO KETONES WITH 1-ALKENYLBORON, ARYLBORON, OR ALKYLBORON COMPOUNDS - A FACILE SYNTHESIS OF KETONES AND THEIR ENOL ACETATES

被引：21

作者：

ABE, S ^{[1
]}

MIYAURA, N ^{[1
]}

SUZUKI, A ^{[1
]}

机构：

[1] HOKKAIDO UNIV, FAC ENGN, DEPT APPL CHEM, SAPPORO, HOKKAIDO 060, JAPAN

来源：

BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN | 1992年 / 65卷 / 10期

关键词：

D O I：

10.1246/bcsj.65.2863

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The synthesis of stereodefined enol acetates of ketones is readily accomplished by palladium-catalyzed cross-coupling reaction between alkyl-, aryl-, or 1-alkenylboron reagents with enol acetates of alpha-bromo ketones. Hydroboration of alkene with 9-BBN, followed by coupling with (Z)-2-ethoxy-1-bromoethene gives the enol ether of aldehyde. These enol acetates and ethers are readily deprotected to give corresponding ketones and aldehydes in high yields.

引用

页码：2863 / 2865

页数：3

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