MURINE AIDS IS AN ANTIGEN-DRIVEN DISEASE - REQUIREMENTS FOR MAJOR HISTOCOMPATIBILITY COMPLEX CLASS-II EXPRESSION AND CD4+ T-CELLS

被引:43
|
作者
GIESE, NA [1 ]
GIESE, T [1 ]
MORSE, HC [1 ]
机构
[1] NCI,GENET LAB,BETHESDA,MD 20892
关键词
D O I
10.1128/JVI.68.9.5819-5824.1994
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Murine AIDS (MAIDS) is a complex syndrome of lymphoproliferation and immunodeficiency induced by a replication-defective murine leukemia virus (BM5def) that encodes Pr60(gag) as its only product. It has been suggested that the gag polyprotein is responsible for vigorous antigenic stimulation of CD4(+) T cells and generalized secondary activation of the immune system. This model was tested first by infecting mice (C2K/O) that lack class II major histocompatibility complex molecules required for presentation of antigens to CD4(+) T cells. C2K/O mice expressed BM5def at high levels but did not develop MAIDS either when unmanipulated or following transfer of CD4(+) T cells. Second, B6 mice reconstituted with C2K/O bone marrow cells had normal frequencies of B cells (class II negative) and CD4(+) cells and expressed high levels of BM5def transcripts but did not develop MAIDS; however, MAIDS developed in class II-competent nu/nu mice reconstituted with CD4(+) T cells and in C2K/O mice reconstituted with B6 bone marrow to give class II-positive B cells and with purified CD4(+) T cells. These results indicate that induction of MAIDS by BM5def is antigen driven and is dependent on expression of major histocompatibility complex class II molecules on antigen-presenting cells and the presence of CD4(+) T cells.
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页码:5819 / 5824
页数:6
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