SUGGESTED MECHANISMS FOR THE PRODUCTION OF 4-HYDROXY-2-NONENAL FROM THE AUTOXIDATION OF POLYUNSATURATED FATTY-ACIDS

被引：190

作者：

PRYOR, WA

PORTER, NA

机构：

[1] Biodynamics Institute, Louisiana State University, Baton Rouge

[2] Department of Chemistry, Paul M. Gross Chemical Laboratory, Duke University, Durham

来源：

FREE RADICAL BIOLOGY AND MEDICINE | 1990年 / 8卷 / 06期

关键词：

4-hydroxy-2-nonenal; Aldehyde; Free radicals; Hydroperoxide; Lipid peroxidation;

D O I：

10.1016/0891-5849(90)90153-A

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Autoxidation of certain polyunsaturated fatty acids (PUFA) produces 4-hydroxy-2-nonenal (HNE). Of all of the many products produce during PUFA autoxidation, HNE is one of the more interesting. It is remarkably cytotoxic, and appears to play a role in certain types of pathology. This manuscript suggests, for the first time, mechanisms that rationalize the production of HNE from PUFA that undergo autoxidation. The mechanisms requires, in agreement with the facts, an n-6 fatty acid and iron catalysis. © 1990.

引用

页码：541 / 543

页数：3

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