THE ROLE OF HLA CLASS-II ANTIGENS IN THE INDUCTION OF CYTOTOXIC T-LYMPHOCYTES

被引：1
|
作者：
DEMESOVA, V
BUC, M
FERENCIK, S
SASAZUKI, T
SHAWKATOVA, I
PORUBSKA, S
机构：
[1] UNIV ESSEN GESAMTHSCH KLINIKUM,INST IMMUNOL,W-4300 ESSEN,GERMANY
[2] KYUSHU UNIV,MED INST BIOREGULAT,DEPT GENET,HIGASHI KU,FUKUOKA 812,JAPAN
来源：
EUROPEAN JOURNAL OF IMMUNOGENETICS | 1995年 / 22卷 / 06期
关键词：
D O I：
10.1111/j.1744-313X.1995.tb00280.x
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Investigation of pairs of unrelated persons mismatched for a particular HLA-DQB1 or -DPB1 gene on the induction of cytotoxic T lymphocytes (CTL) revealed that HLA-DQ and HLA-DP antigens provided a slight proliferative stimulus which was, however, sufficient for the generation of CTL. Monomorphic anti-DO and anti-DP monoclonal antibodies abrogated the induction of cytotoxic response. The results indicate that the HLA-DQ and HLA-DP antigens play a similar role to HLA-DR specificities in clinical bone marrow transplantation.
引用
收藏
页码：425 / 434
页数：10
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