Adjuvant bisphosphonates in breast cancer: has the time come?

被引：0

作者：

Gagliato, Debora ^{[1
]}

Chavez-MacGregor, Mariana ^{[1
]}

机构：

[1] Univ Texas MD Anderson Canc Ctr, Dept Breast Med Oncol, 1155 Herman P Pressler CPB5 3550, Houston, TX 77030 USA

来源：

BREAST CANCER MANAGEMENT | 2013年 / 2卷 / 04期

关键词：

D O I：

10.2217/BMT.13.28

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Bone metabolism is highly affected by changes in ovarian function, which is a common consequence of the treatment of breast cancer patients. Osteopenia and osteoporosis increase the risk of fractures, which are associated with profound loss in quality of life. Bisphosphonates are used with the objective of preventing bone loss in patients with osteoporosis, but data suggest that agents such as zoledronic acid might play a role in the prevention of metastatic disease and therefore have been evaluated in numerous randomized trials in the adjuvant setting. This review article will discuss and analyze the available data regarding the use of bisphosphonates in the adjuvant setting for breast cancer patients. It will focus on the use of bisphosphonates as anticancer agents, but will also discuss the use of these agents for the prevention of bone loss.

引用

页码：327 / 337

页数：11

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