IN-VIVO LOCALIZED PROTON NMR-SPECTROSCOPY OF THIAMINE-DEFICIENT RAT-BRAIN

被引：19
|
作者：
LEE, H [1 ]
TARTER, T [1 ]
HOLBURN, GE [1 ]
PRICE, RR [1 ]
WEINSTEIN, DD [1 ]
MARTIN, PR [1 ]
机构：
[1] VANDERBILT UNIV,MED CTR,DEPT PSYCHIAT,NASHVILLE,TN 37232
来源：
MAGNETIC RESONANCE IN MEDICINE | 1995年 / 34卷 / 03期
关键词：
THIAMINE; ALCOHOLISM; RAT BRAIN; PROTON MRS;
D O I：
10.1002/mrm.1910340306
中图分类号：
R8 [特种医学]; R445 [影像诊断学];
学科分类号：
1002 ; 100207 ; 1009 ;
摘要：
Thiamine deficiency (TD) in rats produces lesions similar to those found in humans suffering from Wernicke's encephalopathy, an organic mental disorder associated with alcoholism. Male Sprague-Dawley rats (n = 29) were deprived of thiamine via a regimen of thiamine-deficient chow and daily intraperitoneal injections of the thiamine antagonist pyrithiamine hydrobromide, Spectra were obtained by using the STEAM sequence. No significant change occurred in the ratio of Cr/NAA, while the ratio of Cho/NAA declined significantly (60 +/- 11%) on Day 14. Eleven rats received intraperitoneal injections of thiamine hydrochloride at the end of 12 days, and dose-dependent recovery in Cho/NAA was observed.
引用
收藏
页码：313 / 318
页数：6
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