SYNTHESIS OF A BIODEGRADABLE POLYMERIC SUPRAMOLECULAR ASSEMBLY FOR DRUG-DELIVERY

被引：79
|
作者：
OOYA, T
MORI, H
TERANO, M
YUI, N
机构：
[1] School of Materials Science, Japan Advanced Institute of Science, Tatsunokuchi, 923-12
来源：
MACROMOLECULAR RAPID COMMUNICATIONS | 1995年 / 16卷 / 04期
关键词：
D O I：
10.1002/marc.1995.030160405
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
A novel design of a biodegradable carrier for drug delivery was established by constructing a supramolecular assembly of drugs and polymer backbones without any covalent bonds. A biodegradable polyrotaxane was synthesized in which alpha-cyclodextrins (alpha-CDs) as drug carriers were threaded onto poly(ethylene glycol) chains which then were capped at each chain end by L-phenylalanine via peptide linkages. The release of alpha-CDs was observed only when the terminal peptide linkages were degraded.
引用
收藏
页码：259 / 263
页数：5
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