REPRODUCIBILITY STUDY OF POSTERIOR SUBCAPSULAR OPACITIES ON THE NEI RETROILLUMINATION IMAGE-ANALYSIS SYSTEM

被引:2
|
作者
LOPEZ, MLL
DATILES, MB
PODGOR, MJ
VIVINO, MA
MAHURKAR, AA
LASA, SM
机构
[1] NEI,OPHTHALM GENET & CLIN SERV BRANCH,CATARACT & CORNEA SECT,BETHESDA,MD 20892
[2] NIH,DIV COMP RES & TECHNOL,COMPUTAT BIOSCI & ENGN LAB,BETHESDA,MD 20892
关键词
CATARACT QUANTIFICATION; IMAGE ANALYSIS; POSTERIOR SUBCAPSULAR CATARACT; REPRODUCIBILITY; RETROILLUMINATION;
D O I
10.1038/eye.1994.162
中图分类号
R77 [眼科学];
学科分类号
100212 ;
摘要
We developed a semi-automated retroillumination image analysis system which combines speed, ease of operation and interactive analysis. The system measures cataract area and integral of cataract density (ID). For system reproducibility evaluation, 20 eyes with posterior subcapsular opacities were captured twice by two photographers. Variability was estimated under a random effects analysis of variance model. Measurement errors for area and for ID were each small contributors to total variability (the sum of variability between study eyes plus measurement error), being 0.4% and 0.1% respectively. The largest contributor to area measurement error was image analysis variability (97%). For ID measurement error, the variability in images (44%) and in image analysis (46%) were major contributors. The reproducibility is comparable to previously described retroillumination analysis systems. This easy to use system may therefore be useful in clinical research studies including possible clinical trials of anti-cataract drugs.
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页码:657 / 661
页数:5
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