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EUKARYOTIC REPLICATION ORIGINS AS PROMOTERS OF BIDIRECTIONAL DNA-SYNTHESIS
被引:31
|作者:
HEINTZ, NH
DAILEY, L
HELD, P
HEINTZ, N
机构:
[1] ROCKEFELLER UNIV,MOLEC BIOL LAB,NEW YORK,NY 10021
[2] ROCKEFELLER UNIV,HOWARD HUGHES MED INST,NEW YORK,NY 10021
关键词:
D O I:
10.1016/0168-9525(92)90298-I
中图分类号:
Q3 [遗传学];
学科分类号:
071007 ;
090102 ;
摘要:
Recent work in yeast shows that eukaryotic origins of DNA replication are multipartite regulatory elements resembling promoters of transcription. As for the regulation of transcription, accessory transcription factors appear to function in concert with bask origin recognition factors to regulate initiation of DNA synthesis at specific subsets of origins. The participation of transcription factors in the regulation of DNA replication may facilitate temporal control of transcription and replication during the cell cycle, as well as providing a mechanism for integrating origin selection with the cellular transcriptional program.
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页码:376 / 381
页数:6
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