REDUCTION OF METASTASES OF LEWIS LUNG-CARCINOMA BY AN AYURVEDIC FOOD SUPPLEMENT IN MICE

In this investigation we studied the effect of oral feeding of an Ayurvedic Rasayana (health promoting/ therapeutic preparation) called Maharishi Amrit Kalash-4 (M-4) on metastasis of Lewis Lung Carcinoma (LLC) in mice. C57BL/6 female mice were fed either chow containing M-4 or stadtard laboratory chow and inoculated subcutaneously with 5x10(5) LLC tumor cells. Animals were sacrificed 1-3 days after first animal died in either group (4-5 weeks). The animals receiving M-4-containing chow had significantly (P<.01) fewer and smaller metastatic lung nodules. This result shows that ingestion of this food supplement reduces LLC metastases in mice. Though the mechanism of M-4's action is not known, the beneficial effect is apparent.