LYMPHOCYTE SUBPOPULATIONS IN LONG-TERM DIALYSIS PATIENTS - A CASE-CONTROLLED STUDY OF THE EFFECTS OF BLOOD-TRANSFUSION

Lymphocyte subsets in a group of intensely transfused (> 10 units/year) patients on long‐term hemodialysis were compared with those in a carefully controlled population of lightly transfused (1–10 units/year, no units during study period) long‐term dialysis patients. The data confirm previous reports of lymphopenia and a symmetrical reduction of both T‐ and B‐cell subpopulations in patients on long‐term dialysis. Eleven (36.7%) of 30 intensely transfused dialysis (ITD) patients had a low T8 population when expressed as a percentage value, while 0 of 25 lightly transfused dialysis (LTD) control patients exhibited a low percentage of T8 cells. There were no significant absolute differences between the lymphocyte subsets in the ITD and LTD patients. These data contrast with previous reports of other groups of ITD patients in whom there was an observed increase in T8 cytotoxic suppressor cells. Our findings suggest that the immunologic effects of renal failure and long‐term dialysis largely override the increase in T8 lymphocyte subsets observed in other groups of transfused patients. There is little difference between ITD and LTD patients, but both groups are significantly different from nontransfused controls. Further longitudinal studies are needed in completely untransfused patients to resolve the contribution of minimal transfusion therapy to the immunologic deficits observed in long‐term dialysis patients. 1990 AABB