INDUCTION OF MAMMARY EPITHELIAL HYPERPLASIAS AND MAMMARY-TUMORS IN TRANSGENIC MICE EXPRESSING A MURINE MAMMARY-TUMOR VIRUS/ACTIVATED C-SRC FUSION GENE

被引：70
|
作者：
WEBSTER, MA
CARDIFF, RD
MULLER, WJ
机构：
[1] MCMASTER UNIV,INST MOLEC BIOL,HAMILTON,ON L8S 4K1,CANADA
[2] MCMASTER UNIV,DEPT BIOL,BIOTECHNOL CANC RES GRP,HAMILTON,ON L8S 4K1,CANADA
[3] MCMASTER UNIV,DEPT PATHOL,HAMILTON,ON L8S 4K1,CANADA
[4] UNIV CALIF DAVIS,SCH MED,DEPT PATHOL,DAVIS,CA 95616
来源：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1995年 / 92卷 / 17期
关键词：
HYPERPLASIA; MAMMARY TUMORIGENESIS; LACTATION DEFECT;
D O I：
10.1073/pnas.92.17.7849
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Activation of the c-Src tyrosine kinase has been implicated as an important step in the induction of mammary tumors in both mice and humans. To directly assess the effect of mammary gland-specific expression of activated c-Src, we established transgenic mice that carry a constitutively activated form of c-src under transcriptional control of the murine mammary tumor virus long terminal repeat. Female mice derived from several independent transgenic lines lactate poorly as a consequence of an impairment in normal mammary epithelial development, In addition to this lactation defect, female mice frequently develop mammary epithelial hyperplasias, which occasionally progress to frank neoplasias. Taken together, these observations suggest that expression of activated c-Src in the mammary epithelium of transgenic mice is not sufficient for induction of mammary tumors.
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页码：7849 / 7853
页数：5
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