Role of the IRS-1 and/or -2 in the pathogenesis of insulin resistance in Dahl salt-sensitive (S) rats

被引：2
|
作者：
Shehata, Marlene F. [1 ]
机构：
[1] Univ Ottawa, Fac Med, Dept Cellular & Mol Med, Ottawa, ON, Canada
来源：
HEART INTERNATIONAL | 2009年 / 4卷 / 01期
关键词：
Dahl S rats; insulin resistance; salt-sensitivity; insulin signaling pathway; genetic contributors; molecular contributors;
D O I：
10.4081/hi.2009.e6
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Insulin resistance is a common finding in hypertensive humans and animal models. The Dahl salt-sensitive (S) rat is an ideal model of genetically predetermined insulin resistance and salt-sensitive hypertension. Along the insulin signaling pathway, the insulin receptor substrates 1 and 2 (IRS-1 and -2) are important mediators of insulin signaling. IRS-1 and/or IRS-2 genetic variant(s) and/or enhanced serine phosphorylation correlate with insulin resistance. The present commentary was designed to highlight the significance of IRS-1 and/or -2 in the pathogenesis of insulin resistance. An emphasis will be given to the putative role of IRS-1 and/or -2 genetic variant(s) and serine phosphorylation in precipitating insulin resistance.
引用
收藏
页码：22 / 24
页数：3
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