NMDA RECEPTORS ARE INVOLVED IN SPONTANEOUS BURST FIRING OF DOPAMINERGIC MESENCEPHALIC NEURONS

被引：0
|
作者：
CHERGUI, K [1 ]
CHARLETY, PJ [1 ]
AKAOKA, H [1 ]
BRUNET, JL [1 ]
SAUNIER, CF [1 ]
BUDA, M [1 ]
SVENSSON, TH [1 ]
CHOUVET, G [1 ]
机构：
[1] KAROLINSKA INST,DEPT PHARMACOL,S-10401 STOCKHOLM 60,SWEDEN
来源：
COMPTES RENDUS DE L ACADEMIE DES SCIENCES SERIE III-SCIENCES DE LA VIE-LIFE SCIENCES | 1991年 / 313卷 / 02期
关键词：
D O I：
暂无
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
In the rat, somatodendritic application of the NMDA antagonist AP-5, within the Substantia Nigra Zona Compacta and Ventral Tegmental Area, either by micro-iontophoresis or pressure ejection, reduces burst firing of dopamine neurons. Similar local application of the non-NMDA antagonist CNQX does not affect their firing pattern. These results indicate that, in vivo, excitatory amino acid afferents participate through NMDA receptors in the control of the spontaneous burst firing of midbrain dopamine neurons.
引用
收藏
页码：139 / 144
页数：6
相关论文
共 50 条
  • [1] Burst firing in midbrain dopaminergic neurons
    Overton, PG
    Clark, D
    BRAIN RESEARCH REVIEWS, 1997, 25 (03) : 312 - 334
  • [2] APAMIN INCREASES NMDA-INDUCED BURST-FIRING OF RAT MESENCEPHALIC DOPAMINE NEURONS
    SEUTIN, V
    JOHNSON, SW
    NORTH, RA
    BRAIN RESEARCH, 1993, 630 (1-2) : 341 - 344
  • [3] SUBTHALAMIC NUCLEUS MODULATES BURST FIRING OF NIGRAL DOPAMINE NEURONS VIA NMDA RECEPTORS
    CHERGUI, K
    AKAOKA, H
    CHARLETY, PJ
    SAUNIER, CF
    BUDA, M
    CHOUVET, G
    NEUROREPORT, 1994, 5 (10) : 1185 - 1188
  • [4] Group I metabotropic glutamate receptors activate burst firing in rat midbrain dopaminergic neurons
    Prisco, S
    Natoli, S
    Bernardi, G
    Mercuri, NB
    NEUROPHARMACOLOGY, 2002, 42 (03) : 289 - 296
  • [5] Contribution of AMPA and NMDA receptors in the spontaneous firing patterns of single neurons in autaptic culture
    Hattori, Kouhei
    Hayakawa, Takeshi
    Nakanishi, Akira
    Ishida, Mihoko
    Yamamoto, Hideaki
    Hirano-Iwata, Ayumi
    Tanii, Takashi
    BIOSYSTEMS, 2020, 198
  • [6] BURST FIRING OF MESENCEPHALIC DOPAMINE NEURONS IS INHIBITED BY SOMATODENDRITIC APPLICATION OF KYNURENATE
    CHARLETY, PJ
    GRENHOFF, J
    CHERGUI, K
    DELACHAPELLE, B
    BUDA, M
    SVENSSON, TH
    CHOUVET, G
    ACTA PHYSIOLOGICA SCANDINAVICA, 1991, 142 (01): : 105 - 112
  • [7] NMDA Receptors in Dopaminergic Neurons Are Crucial for Habit Learning
    Wang, Lei Phillip
    Li, Fei
    Wang, Dong
    Xie, Kun
    Wang, Deheng
    Shen, Xiaoming
    Tsien, Joe Z.
    NEURON, 2011, 72 (06) : 1055 - 1066
  • [8] Modulation of Burst Firing of Neurons in Nucleus Reticularis of the Thalamus by GluN2C-Containing NMDA Receptors
    Liu, Jinxu
    Shelkar, Gajanan P.
    Zhao, Fabao
    Clausen, Rasmus P.
    Dravid, Shashank M.
    MOLECULAR PHARMACOLOGY, 2019, 96 (02) : 193 - 203
  • [9] TONIC ACTIVATION OF NMDA RECEPTORS CAUSES SPONTANEOUS BURST DISCHARGE OF RAT MIDBRAIN DOPAMINE NEURONS INVIVO
    CHERGUI, K
    CHARLETY, PJ
    AKAOKA, H
    SAUNIER, CF
    BRUNET, JL
    BUDA, M
    SVENSSON, TH
    CHOUVET, G
    EUROPEAN JOURNAL OF NEUROSCIENCE, 1993, 5 (02) : 137 - 144
  • [10] Survival promotion of mesencephalic dopaminergic neurons by depolarizing concentrations of K+ requires concurrent inactivation of NMDA or AMPA/kainate receptors
    Douhou, A
    Troadec, JD
    Ruberg, M
    Raisman-Vozari, R
    Michel, PP
    JOURNAL OF NEUROCHEMISTRY, 2001, 78 (01) : 163 - 174
12345