INDUCTION OF MICRONUCLEI IN V79 CHINESE-HAMSTER CELLS BY HYDROQUINONE AND ECONAZOLE NITRATE

被引：11
|
作者：
ELLARD, S
PARRY, EM
机构：
[1] Molecular Biology Research Group, School of Biological Sciences, University College of Swansea, Swansea, SA2 8PP, Singleton Park
来源：
MUTATION RESEARCH | 1993年 / 287卷 / 01期
关键词：
MICRONUCLEI; INDUCTION; CHINESE HAMSTER CELLS; V79; HYDROQUINONE; ECONAZOLE NITRATE;
D O I：
10.1016/0027-5107(93)90147-8
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Two suspect aneugens (hydroquinone and econazole nitrate) were examined for their ability to induce micronuclei in a number of V79 Chinese hamster cell lines which express rat cytochrome P-450 cDNAs. Hydroquinone elevated micronucleated cell frequencies in a dose-dependent manner in cell lines V79, XEM2 (expresses CYP1A1) and SD1 (expresses CYP2B1). Econazole nitrate was an effective inducer of micronuclei over a narrow dose range in cell lines V79, XEM2 and XEMd-MZ (expresses CYP1A2). The different cell lines showed similar responses to the test agents, indicating that hydroquinone is not a substrate for biotransformation by rat CYP1A1 or CYP2B1, nor is econazole nitrate biotransformed by rat CYP1A1 or CYP1A2.
引用
收藏
页码：87 / 91
页数：5
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