Polymorphism rs738409 of the adiponutrin gene (PNPLA3) among the indigenous residents of the North

被引：0
|
作者：
Dyakonova, A. T. [1 ]
Pavlova, N., I [1 ]
Soloveva, N. A. [1 ]
Filippova, N. P. [1 ]
Dodokhov, V. V. [1 ]
Neustroeva, L. M. [1 ]
Varlamova, M. A. [1 ]
Kurtanov, K. A. [1 ]
机构：
[1] Yakutsk Sci Ctr Complex Med Problems, Fed State Budget Sci Inst, Yakutsk, Russia
来源：
YAKUT MEDICAL JOURNAL | 2018年 / 02期
关键词：
diabetes mellitus type 2; insulin resistance; adiponutrin gene; polymorphism;
D O I：
10.25789/YMJ.2018.62.14
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
In order to detect non-alcoholic fatty liver disease (NAFLD) we studied polymorphism rs738409 of adiponutrin gene (PNPLA3) among native northerners in the Sakha (Yakutia) Republic. Epidemiological data indicate the frequent combination of type 2 diabetes and NAFLD, characterized by accumulation of lipids both in the hepatocytes themselves and in the intercellular space. Recently, great importance is attached to the genetic conditionality of NAFLD.
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页码：45 / 47
页数：3
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