Retrospective evaluation of risk determinants in prodromal period with a group of schizophrenia patients

Purpose: This study aims to investigate the significance of risk determiners in the occurence of schizophrenia. and the link between the severity of determiners and the duration to full-blown schizophrenia. Material and Methods: Patients older than 18 years old, diagnosed with schizophrenia are included in our study. SOPS (Scale of Prodromal Symptoms) is applied to determine the risk of schizophrenia prodromal period, scale scores are calculated and patients are classified in accordance to risk syndrome criteria defined in SIPS (Structured Interview for Prodromal Symptoms). Results: Prodromal symptoms are detected in 68 of 100 patients. Of those 68 patients, 47 met the criteria for Attenuated Positive Prodromal Syndrome (APPS), 20 met the criteria for Brief Intermittent Psychotic Syndrome (BIPS), 24 met the criteria for Genetic Risk and Deterioration Syndrome (GRDS), 67 met the criteria for Psychotic Syndrome (PS), 44 met the criteria for Attenuated Psychosis Syndrome (APS) in DSM-5. Grandiosity, perceptual abnormalities/hallucinations, poverty of thought, deterioration in a role functioning, peculiar behaviour and appearance, decreased tolerance to normal stress are manifested to be meaningful in APPS, Conclusion: It's clear that prodromal symptoms are increasing markedly the odds of psychosis and schizophrenia occurance in respect to normal population. Nevertheless, further customization and elaboration of risk determining criteria, searching and displaying neurobiological risk factors among criteria, will help to reliably identify risk groups and detect disorder in prodromal period.