Breast cancer proliferative activity: Is it the source of serum free DNA?

被引：2
|
作者：
Hewala, Taha I. [1 ]
El-Moneim, Nadia A. Abd [2 ]
机构：
[1] Alexandria Univ, Med Res Inst, Dept Radiat Sci, 165 Horria Ave,El Hadara, Alexandria 21561, Egypt
[2] Alexandria Univ, Med Res Inst, Dept Canc Management & Res, Alexandria 21561, Egypt
来源：
ALEXANDRIA JOURNAL OF MEDICINE | 2013年 / 49卷 / 04期
关键词：
Breast cancer; Proliferative activity; Diagnosis; Prognosis; DNA; TPS; CEA;
D O I：
10.1016/j.ajme.2013.03.004
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Aim: To study the relationship between serum DNA and breast cancer proliferative activity, then compare the diagnostic and prognostic values of serum DNA, TPS and CEA. Subjects and methods: A total of 100 breast cancer patients before surgery and 50 apparently healthy controls were analyzed for serum DNA, TPS and CEA. Results: Serum DNA levels were nonsignificantly correlated with serum TPS levels. Serum DNA, TPS and CEA levels were significantly higher in patients than controls. Using ROC curve analysis, serum TPS and DNA had the highest AUC compared to serum CEA. Neither serum TPS, DNA nor CEA correlated with breast cancer clinicopathological data. Only serum CEA was significantly correlated with patients' disease-free survival. Conclusion: Neither Breast cancer mass nor proliferative activity is the source of serum free DNA. Serum TPS is superior to DNA and CEA as a diagnostic marker for breast cancer. Only preoperative serum CEA has a prognostic role in predicting relapse of breast cancer patients, but not serum TPS or DNA. (C) 2013 Production and hosting by Elsevier B.V. on behalf of Alexandria University Faculty of Medicine.
引用
收藏
页码：337 / 341
页数：5
相关论文
共 50 条
  • [1] DNA-PLOIDY, PROLIFERATIVE ACTIVITY, AND CONCANAVALIN-A REACTIVITY IN BREAST-CANCER
    PAYDAS, S
    SARPEL, S
    GILMANSACHS, A
    TUNCER, I
    PEHLIVAN, S
    TUNALI, N
    ZORLUDEMIR, S
    BURGUT, R
    KUCUK, O
    JOURNAL OF SURGICAL ONCOLOGY, 1994, 56 (01) : 21 - 24
  • [2] Effect of adjuvant chemotherapy on integrity of free serum DNA in patients with breast cancer
    Deligezer, Ugur
    Eralp, Yesim
    Akisik, Elif Z.
    Akisik, Ebru E.
    Saip, Pinar
    Topuz, Erkan
    Dalay, Nejat
    CIRCULATING NUCLEIC ACIDS IN PLASMA AND SERUM V, 2008, 1137 : 175 - 179
  • [3] Elevated Free Triiodothyronine Is Associated With Increased Proliferative Activity in Triple-negative Breast Cancer
    Nisman, Benjamin
    Allweis, Tanir M.
    Carmon, Einat
    Kadouri, Luna
    Maly, Bella
    Maimon, Ofra
    Meirovitz, Amichay
    Peretz, Tamar
    ANTICANCER RESEARCH, 2021, 41 (02) : 949 - 954
  • [4] Proliferative activity of tumor cells as a prognostic factor in breast cancer
    Gulyak, NS
    Sergeeva, NS
    Slavnova, EN
    Chissov, VI
    Babarina, AV
    Demidov, VP
    Pak, DD
    Dzhubalieva, SK
    BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE, 1995, 120 (08) : 858 - 860
  • [5] The prognostic relevance of estimates of proliferative activity in early breast cancer
    Offersen, BV
    Sorensen, FB
    Knoop, A
    Overgaard, J
    HISTOPATHOLOGY, 2003, 43 (06) : 573 - 582
  • [6] Comparison of different methods for evaluation of the proliferative activity in breast cancer
    Mink, D
    VillenaHeinsen, C
    Tossounidis, I
    Schmidt, W
    GYNAKOLOGISCH-GEBURTSHILFLICHE RUNDSCHAU, 1995, 35 : 53 - 56
  • [7] PROLIFERATIVE ACTIVITY AND PLOIDY ABNORMALITY IN HUMAN-BREAST CANCER
    RABER, M
    BARLOGIE, B
    LATREILLE, J
    FU, CT
    FRITSCHE, H
    CELL AND TISSUE KINETICS, 1980, 13 (06): : 682 - 682
  • [8] The prognostic relevance of estimates of proliferative activity in early breast cancer
    Heatley, MK
    Maxwell, P
    Whiteside, C
    Ewing, P
    Toner, PG
    HISTOPATHOLOGY, 2005, 46 (01) : 110 - 111
  • [9] Prognostic value of DNA parameters and proliferative activity in stomach cancer
    Hartwich, A
    17TH INTERNATIONAL CANCER CONGRESS, VOL 1 AND 2, 1998, : 903 - 908
  • [10] Circulating free DNA in the management of breast cancer
    Shaw, Jacqueline A.
    Stebbing, Justin
    ANNALS OF TRANSLATIONAL MEDICINE, 2014, 2 (01)
12345